Lin WU 武林

Dr. Lin Wu pursued postdoctoral training in immunology and genetics in Dan Littman lab at HHMI/NYU School of Medicine, in single cell technology in Rahul Satija lab as a joint postdoc at New York Genome Center, and in cellular metabolism through intimate collaborations with Alec Kimmelman, Richard Possemato, Thales Papagiannakopoulos, Michael Pacold, and Drew Jones. Dr. Wu is also an expert in protein biochemistry as being trained during his graduate study in Mingjie Zhang lab at Hong Kong University of Science and Technology. Dr. Wu’ postdoctoral work has made significant contributions to the study of immunology and metabolism: (1) the development of a novel in vivo naive T cell genetic screening system, greatly accelerating in vivo functional study of T cells; (2) the first identification of a gene that is selectively required by pathogenic but dispensable in nonpathogenic Th17 cells, addressing a critical question in the study of Th17 and autoimmunity; and (3) the insight that cellular metabolism can modulate immune cell function in a tissue microenvironment-specific manner, paving new research directions in immunometabolism. In addition, Dr. Wu’s graduate work characterized molecular mechanisms by which three USH I proteins regulate the development of inner ear hair cells and how their mutations lead to deafness. To date, his work has led to publications in Cell and Science etc. (as first author/corresponding author), as well as Nature, Cell, JEM, PNAS etc. (as co-author), and his contribution has been recognized by a National Multiple Sclerosis Society Postdoctoral Fellowship Award, the NIH/NCI Institutional Postdoctoral Training Grant Award, the Hong Kong Young Scientist Award, and with an invitation to chair a Keystone symposium session etc. Building upon his past going forward, Dr. Wu will lead his team to address critical questions in the areas of immune regulation by microbiota, metabolism, as well as its impact on physiology&pathobiology at local and distal organs. 

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EDUCATION AND PROFESSIONAL EXPERIENCE

• 2013-2021, HHMI/NYU School of Medicine, Postdoc, Dan Littman Lab

• 2015-2021, New York Genome Center, joint-Postdoc, Rahul Satija Lab

• 2007-2012 Hong Kong University of Science and Technology, Ph.D., Biochemistry, Mingjie Zhang Lab

• 2004-2006 Sun Yat-sen University, Master, Molecular and Cellular Biology, Limin Zheng Lab

• 2000-2004 Sun Yat-sen University, Bachelor, Biotechnology

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HONORS

• 2021 National Natural Science Fund for Excellent Young Scientists Fund Program (Overseas) （China)

• 2021 Oversea High-Caliber Personnel Award, Level B, ShenZhen

• 2021 NIH/NCI Institutional Training Grant Award: Molecular Oncology and Immunology Training Grant (USA)

• 2014-2017 National Multiple Sclerosis Society Postdoctoral Fellowship Award (NMSS) (USA)

• 2011 Hong Kong Young Scientist Award (Hong Kong Institution of Science)

• 2010 Postgraduate Achievement Award (Hong Kong University of Science and Technology)

• 2005 Excellent Graduate Student Scholarship of Sun Yat-sen University

• 2000-2004 Kaisi Scholarship of Sun Yat-sen University

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INVITED PRESENTATION

• July 2021: Cell and Experimental Biology Conference. Featured Speaker, “Metabolic plasticity enables microenvironment specific modulation of Th17 cells”.

• April 2019: Keystone symposium - Immunometabolism, Metaflammation and Metabolic Disorders. Session Chair, “Selective redundancy in metabolism network allows for specific inhibition of inflammatory Th17 cells”.

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PUBLICATION

• Xu H, Wu L, Nguyen H, Mesa KR, Raghavan V, Episkopou V, Littman DR. Arkadia-SKI/SnoN signaling cascade differentially regulates TGF-β-induced iTreg and Th17 cell differentiation. JEM. 2021. 218 (11): e20210777.

• Lee JY, Hall JA, Pokrovskii M, Kroehling L, Wu L, Littman DR. RORα enforces stability of the T-helper-17 cell effector program. BioRxiv. Doi: https://doi.org/10.1101/2020.12.15.422921.

• Wu L#, Hollinshead KER, Hao Y, Au C, Kroehling L, Ng C, Lin WY, Li D, Silva HM, Shin J, Lafaille JJ, Possemato R, Pacold ME, Papagiannakopoulos TY, Kimmelman AC, Satija R, Littman DR#. Niche-selective inhibition of pathogenic Th17 cells by targeting metabolic redundancy. Cell. 2020. 182: 641-654. (# Corresponding author).

• Lee JY, Hall JA, Kroehling L, Wu L, Najar T, Nguyen HH, Lin WY, Yeung ST, Silver HM, Li D, Hine A, Loke P, Hudesman D, Martin JC, Kenigsberg E, Merad M, Khanna KM, Littman DR. Serum amyloid A proteins induce pathogenic Th17 cells and promote inflammatory disease. Cell, 2020. 180: 79-91.

• Hang S, Paik D, Devlin AS, Jamma T, Lu J, Ha S, Nelson BN, Kelly SP, Wu L, Zheng Y, Rastinejad F, Krout MR, Fischbach MA, Littman DR, Huh JR. Bile acid metabolites control Th17 and Treg cell differentiation. Nature, 2019. 576, 143–148.

• Ng C, Aichinger M, Nguyen T, Au C, Najar T, Wu L, Mesa KR, Liao W, Quivy JP, Hubert B, Almouzni G, Zuber J, Littman DR. The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells. Genes Dev. 2019. 33: 669-683.

• Wu L*, Pan L*, Zhang C, Zhang M. Large protein assemblies formed by multivalent interactions between cadherin23 and harmonin suggest a stable anchorage structure at the tip link of stereocilia. JBC. 2012. 287: 33460-33471 (* equal contribution)

• Wu L*, Pan L*, Wei Z, Zhang M. Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo. Science. 2011. 331:757-760 (* equal contribution)

• Yan J, Pan L, Chen X, Wu L, Zhang M. The structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteins. PNAS. 2010. 107: 4040-4045.

• Pan L, Yan J, Wu L, Zhang M. Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin23. PNAS. 2009. 106: 5575-5580.